accurate quantification of lipid species by electrospray ionization mass spectrometry — meets a key challenge in lipidomics准确量化的脂质物种通过电喷雾质谱u2014u2014lipidomics遇到了一个关键的挑战.pdfVIP

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accurate quantification of lipid species by electrospray ionization mass spectrometry — meets a key challenge in lipidomics准确量化的脂质物种通过电喷雾质谱u2014u2014lipidomics遇到了一个关键的挑战.pdf

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accurate quantification of lipid species by electrospray ionization mass spectrometry — meets a key challenge in lipidomics准确量化的脂质物种通过电喷雾质谱u2014u2014lipidomics遇到了一个关键的挑战

Metabolites 2011, 1, 21-40; doi:10.3390/metabo1010021 OPEN ACCESS metabolites ISSN 2218-1989 /journal/metabolites/ Review Accurate Quantification of Lipid Species by Electrospray Ionization Mass Spectrometry — Meets a Key Challenge in Lipidomics Kui Yang 1 and Xianlin Han 2,* 1 Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; E-Mail; kyang@ (K.Y.) 2 Sanford-Burnham Medical Research Institute, Orlando, FL 32827, USA * Author to whom correspondence should be addressed; E-Mail: xhan@; Tel.: +1-407-745-2139; Fax: +1-407-745-2013. Received: 8 October 2011; in revised form: 2 November 2011 / Accepted: 4 November 2011 / Published: 11 November 2011 Abstract: Electrospray ionization mass spectrometry (ESI-MS) has become one of the most popular and powerful technologies to identify and quantify individual lipid species in lipidomics. Meanwhile, quantitative analysis of lipid species by ESI-MS has also become a major obstacle to meet the challenges of lipidomics. Herein, we discuss the principles, advantages, and possible limitations of different mass spectrometry-based methodologies for lipid quantification, as well as a few practical issues important for accurate quantification of individual lipid species. Accordingly, accurate quantification of individual lipid species, one of the key challenges in lipidomics, can be practically met. Keywords: electrospray ionization