a survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2010一项调查海洋天然化合物及其衍生物的抗癌活动2010年报告.pdfVIP

Molecules 2011, 16, 5629-5646; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2010 Marc Schumacher, Mareike Kelkel, Mario Dicato and Marc Diederich * Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hôpital Kirchberg, 9, rue Steichen L-2540, Luxembourg; E-Mail: marc.schumacher@lbmcc.lu (M.S.) * Author to whom correspondence should be addressed; E-Mail: marc.diederich@lbmcc.lu; Tel.: +352-2468-4040; Fax: +352-2468-4060. Received: 11 May 2011; in revised form: 31 May 2011 / Accepted: 31 May 2011 / Published: 30 June 2011 Abstract: Although considerable progress in oncology therapeutics has been achieved in the last century, cancer remains one of major death causes in the World and for this reason, the development of novel cancer drugs remains a pressing need. Natural marine compounds represent an interesting source of novel leads with potent chemotherapeutic or chemo-preventive activities. In the last decades, structure-activity-relationship studies have led to the development of naturally-derived or semi-synthetic analogues with improved bioactivity, a simplified synthetic target or less toxicity. We aim here to review a selection of natural compounds with reported anticancer activity isolated of marine sources and their associated analogues published in 2010. Keywords: marine anticancer co