adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity肾上腺切除术刺激下丘脑proopiomelanocortin表达但不正确的食源性肥胖.pdfVIP

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adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity肾上腺切除术刺激下丘脑proopiomelanocortin表达但不正确的食源性肥胖.pdf

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adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity肾上腺切除术刺激下丘脑proopiomelanocortin表达但不正确的食源性肥胖

BMC Physiology BioMed Central Research article Open Access Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity Hideo Makimura1,2, Tooru M Mizuno1,2, Joe Beasley2,3, Jeffrey H Silverstein2,3 and Charles V Mobbs* 1,2 Address: 1Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, USA 10029, USA, 2Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, 10029, USA and 3Department of Anesthesiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, 10029, USA Email: Hideo Makimura - Hideo.Makimura@; Tooru M Mizuno - Tooru.Mizuno@; Joe Beasley - Joseph.Beasley@; Jeffrey H Silverstein - Jeff.Silverstein@; Charles V Mobbs* - Charles.Mobbs@ * Corresponding author Published: 9 June 2003 Received: 30 January 2003 Accepted: 9 June 2003 BMC Physiology 2003, 3:4 This article is available from: /1472-6793/3/4 © 2003 Makimura et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Elevated glucocorticoid production and reduced hypothalamic POMC mRNA can cause obese phenotypes. Conversely, adrenalectomy can reverse obese phenotypes caused by the absence of leptin, a model in which glucocor