fentanyl pretreatment on the impact of rabbit hemorrhagic shock and myocardial injury（芬太尼预处理对兔出血性休克、心肌损伤的影响）.docVIP

Fentanyl pretreatment on the impact of rabbit hemorrhagic shock and myocardial injury [Abstract] Objective: To observe the impact of fentanyl on myocardial ischemia and hypoxia injury in acute hemorrhagic shock in rabbits. Methods: 16 rabbits were randomly divided into saline pretreatment group (C) and fentanyl pretreatment group (F). in accordance with the modified method of Wigger  s writer rabbit model of hemorrhagic shock. bleeding 15 min the two groups were given equal volume of saline and fentanyl to maintain a state of shock 90 min record of bloodletting before (T0) bleeding after 15 (T1), 30 (T2), 45 (T3), 60 (T4), 75 (T5) and 90 min (T6), changes in cardiac function indicators. in bloodletting ago (T0) and bleeding after 60 Determination of serum cardiac troponin I (cTnI) concentration of chemical spectrophotometric method min (T4) and 90min (T6), arterial blood was collected and apical myocardial tissue for pathological electron microscopic examination, take the end of the experiment. Results: Two groups of serum cTnI concentration than T1, T2 and T3 were significantly increased (P lt;0.01) between the two groups of group C serum cTn I increased range is significantly higher than Group F (P lt;0.01), Pathology, electron microscopic examination of myocardial F injury compared with C group reduced. Conclusion: Fentanyl has a protective effect of preconditioning on myocardial injury in rabbits with acute hemorrhagic shock. [Keywords:] fentanyl hemorrhagic shock and cardiac troponin I cardiac injury 0 Introduction Hemorrhagic shock, ischemia and hypoxia can cause many organs of the body injury, the extent of organ damage and the prognosis of patients is directly related to participation in the rescue of these patients in clinical anesthesia often, so the focus of clinical work is to protect the dirty prevents shock to the irreversible direction, the study confirmed the role of fentanyl and other anesthetics can simulate ischemic preconditioning