肿瘤靶向型ph敏感多肽类药物递送系统研究进展advances-药学学报.pdfVIP

药学学报 Acta Pharmaceutica Sinica 20 16, 51 (5): 7 17 724 ·7 17 · 瘤靶向型pH 敏感多肽类药物递送系统研究进展 马银云, 李 莉, 黄海凤, 缑三虎, 倪京满* (兰州大学, 学院, 剂学研究所, 甘肃 兰州 730000) 摘要: pH 敏感性多肽类 物递送系统, 以肿瘤组织酸性的细胞外环境为靶点, 具有肿瘤特异性高、细胞毒性 低, 且能显著提高传统抗癌 物的活性等优点, 近年来受到了广泛的关注。本文总结了5 种类型靶向作用于肿瘤 细胞的pH 敏感性多肽类 物递送系统的研究进展, 对今后肿瘤靶向型 物的设计和应用有重要意义。 关键词: pH 敏感; 多肽; 肿瘤靶向; 物递送系统 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (20 16) 05-0717-08 Advances of tumor targeting peptides drug delivery system with pH-sensitive activities * MA Yin-yun, LI Li, HUANG Hai-feng, GOU San-hu, NI Jing-man (Pharmaceutics Institute, School of Pharmacy, Lanzhou University, Lanzhou 730000, China ) Abstract : The pH-sensitive peptides drug delivery systems, which target to acidic extracellular environment of tumor tissue, have many advantages in drug delivery. They exhibit a high specificity to tumor and low cytotoxicity, which significantly increase the efficacy of traditional anti-cancer drugs. In recent years the systems have received a great attention. The pH-sensitive peptides drug delivery systems can be divided into five types according to the difference in pH-responsive mechanism, type of peptides and carrier materials. This paper summarizes the recent progresses in the field with a focus on the five types of pH-sensitive peptides in drug delivery systems. This may provide a guideline to design and application of tumor targeting drugs. Key words: pH-sensitive; peptide; tumor targeting; drug delivery system 在过去的 10 年 , 化学疗法