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computer simulation allows goal-oriented mechanical ventilation in acute respiratory distress syndrome计算机仿真允许目标明确的急性呼吸窘迫综合征的机械通气
Available online /content/11/2/R36
Vol 11 No 2 Open Access
Research
Computer simulation allows goal-oriented mechanical ventilation
in acute respiratory distress syndrome
Leif Uttman, Helena Ögren, Lisbet Niklason, Björn Drefeldt and Björn Jonson
Department of Clinical Physiology, Lund University, 221 85 Lund, Sweden
Corresponding author: Leif Uttman, leif.uttman@med.lu.se
Received: 8 Jan 2007 Revisions requested: 31 Jan 2007 Revisions received: 21 Feb 2007 Accepted: 12 Mar 2007 Published: 12 Mar 2007
Critical Care 2007, 11:R36 (doi:10.1186/cc5719)
This article is online at: /content/11/2/R36
© 2007 Uttman et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction To prevent further lung damage in patients with aiming at minimal V , plateau pressure 30 cmH O and
T 2
acute respiratory distress syndrome (ARDS), it is important to isocapnia, first by only increasing respiratory rate and then by
avoid overdistension and cyclic opening and closing of using ASPIDS as well.
atelectatic alveoli. Previous studies have demonstrated
protective effects of using low tidal volume (VT), moderate Results VT decreased from 7.2 ± 0.5 ml/kg to 6.6 ± 0.5 ml/kg
positive end-expiratory pressure and low airway
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