原创力文档conditional probabilities of identity of genes at a locus linked to a marker条件概率的身份的基因位点与标记.pdfVIP
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conditional probabilities of identity of genes at a locus linked to a marker条件概率的身份的基因位点与标记
Conditional probabilities of identity of genes
at a locus linked to a marker
C. CHEVALET M. GILLOIS Jacqueline VU TIEN KHANG*
LN.R.A., Laboratoire de Genetique cellulaire,
Station*d’Amélioration genetique des Animaux,
Centre de Recherches de Toulouse, B.P. 12, F 31320 Castanet-Tolosan
Summary
A method is given for determining the probabilities that genes are identical by descent, at a
locus linked to a marker where phenotypic data are available. For tight linkage, such conditional
of differ much from unconditional on the
probabilities identity may very ones ; they depend
dominance relationships between alleles at the marker locus, and on the allelic frequencies. Appli-
cations discussed refer to the calculation of two-locus descent to the validation
general measures,
of pedigrees from polymorphism analysis, and to the statistical detection of an association between
a quantitative trait and a marked region of the genome.
Key words : Identity by descent of genes ; recombination ; genetic polymorphism.
Résumé
Probabilités conditionnées d’identité entre gènes en un locus lié à un marqueur
On donne une méthode pour calculer les probabilités d’identité entre des gènes d’un locus,
conditionnées l’observation des en un locus lié. La méthode
par phénotypes marqueur proposée
réunit 2 approches : les probabilités d’identité conditionnelles, au locus marqueur, sont calculées
en construisant les événements poss
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