注射用奥美拉唑钠（Omeprazole Sodium for Injection）.docVIP

注射用奥美拉唑钠（Omeprazole Sodium for Injection） Omeprazole Sodium for Injection Name used before English name OMEPRAZOLE, SODIUM, FOR, INJECTION Pinyin name ZHUSHEYONG AOMEILAZUONA Drug categories, antacids and anti ulcer drugs The product is white loose loose lump or powder, and the special solvent is colorless transparent liquid. This product for the pharmacology and toxicology of gastric parietal cells of proton pump inhibitors to tubular microtubules and cytoplasmic vesicles H+ and K+-ATP enzymes secreted specifically inhibited cell apical membrane wall structure, which can effectively inhibit gastric acid secretion. Because the H+ and K+-ATP enzymes are the last process of cell wall acid secretion, the product is powerful in acid suppression. It can not only cause the non competitive inhibition of gastrin, histamine, choline and food, the stimulation of the vagus nerve can inhibit gastric acid secretion, but not part of the gastric acid choline or H2 receptor antagonist effect on the secretion of H2 receptor antagonists can inhibit the growth of the ring by two butyl adenosine monophosphate (DCAMP) stimulation gastric acid secretion also had a strong and lasting inhibition. This product it can inhibit the secretion of pepsin on gastric mucosal blood flow, the change is not obvious, does not affect the body temperature, gastric cavity temperature, arterial pressure, venous hemoglobin, arterial PO2 and arterial blood pH. After intravenous injection of this product, the body distributes in the liver, kidney, stomach, duodenum, thyroid and other tissues, the distribution volume is 0.19 ~ 0.48L/kg, and the volume of extracellular fluid is quite. T1/2 ranged from 0.5 to 1 hours, and chronic liver disease was 3 hours. This product is mainly in the liver by cytochrome P450 metabolism, metabolites are sulfur, sulfone and hydroxyl derivatives. There is no effect on the secretion of gastric acid, metabolism is complete, only a small number of excretion in the prototype. Approxi