8-oxoguanine dna glycosylases one lesion, three subfamilies8-oxoguanine dna糖基化酶损伤,三个亚科.pdfVIP

Int. J. Mol. Sci. 2012, 13, 6711-6729; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review 8-Oxoguanine DNA Glycosylases: One Lesion, Three Subfamilies Frédérick Faucher 1,*, Sylvie Doublié 2 and Zongchao Jia 1,* 1 Department of Biomedical and Molecular Sciences, Queen’s University, 18 Stuart Street, Kingston, K7L 3N6, Canada 2 Department of Microbiology and Molecular Genetics, University of Vermont, E314A Given Building, 89 Beaumont Avenue, Burlington, VT 05405, USA; E-Mail: Sylvie.Doublie@ * Authors to whom correspondence should be addressed; E-Mails: Frederick.faucher@queensu.ca (F.F.); jia@queensu.ca (Z.J.); Tel.: +613-533-6277 (Z.J.); Fax: +613-533-2497 (Z.J.). Received: 20 April 2012; in revised form: 14 May 2012 / Accepted: 24 May 2012 / Published: 1 June 2012 Abstract: Amongst the four bases that form DNA, guanine is the most susceptible to oxidation, and its oxidation product, 7,8-dihydro-8-oxoguanine (8-oxoG) is the most prevalent base lesion found in DNA. Fortunately, throughout evolution cells have developed repair mechanisms, such as the 8-oxoguanine DNA glycosylases (OGG), which recognize and excise 8-oxoG from DNA thereby preventing the accumulation of deleterious mutations. OGG are divided into three subfamilies, OGG1, OGG2 and AGOG, which are all involved in the base excis