a cd44highegfrlow subpopulation within head and neck cancer cell lines shows an epithelial-mesenchymal transition phenotype and resistance to treatmentcd44highegfrlow族群在头部和颈部癌症细胞系显示了epithelial-mesenchymal过渡表型和抵抗治疗.pdfVIP

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a cd44highegfrlow subpopulation within head and neck cancer cell lines shows an epithelial-mesenchymal transition phenotype and resistance to treatmentcd44highegfrlow族群在头部和颈部癌症细胞系显示了epithelial-mesenchymal过渡表型和抵抗治疗.pdf

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a cd44highegfrlow subpopulation within head and neck cancer cell lines shows an epithelial-mesenchymal transition phenotype and resistance to treatmentcd44highegfrlow族群在头部和颈部癌症细胞系显示了epithelial-mesenchymal过渡表型和抵抗治疗

A CD44high/EGFRlow Subpopulation within Head and Neck Cancer Cell Lines Shows an Epithelial-Mesenchymal Transition Phenotype and Resistance to Treatment 1 1 1,2 Linnea La Fleur , Ann-Charlotte Johansson , Karin Roberg * ¨ 1 Division of Oto-Rhino-Laryngology and Head Neck Surgery, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, ¨ ¨ ¨ ¨ Linkoping, Sweden, 2 Department of ENT – Head and Neck Surgery, UHL, County Council of Ostergotland, Linkoping, Sweden Abstract Mortality in head and neck squamous cell carcinoma (HNSCC) is high due to emergence of therapy resistance which results in local and regional recurrences that may have their origin in resistant cancer stem cells (CSCs) or cells with an epithelial- mesenchymal transition (EMT) phenotype. In the present study, we investigate the possibility of using the cell surface expression of CD44 and epidermal growth factor receptor (EGFR), both of which have been used as stem cell markers, to identify subpopulations within HNSCC cell lines that differ with respect to phenotype and treatment sensitivity. Three subpopulations, consisting of CD44high/EGFRlow, CD44high/EGFRhigh and CD44low cells, respectively, were collected by