a common genetic variant at 15q25 modifies the associations of maternal smoking during pregnancy with fetal growth the generation r study一个常见基因变异在15 q25修改关联的母亲在怀孕期间吸烟与胎儿生长下一代r研究.pdfVIP

A Common Genetic Variant at 15q25 Modifies the Associations of Maternal Smoking during Pregnancy with Fetal Growth: The Generation R Study 1,2,3 1,2,3 1,4 4 2 Elisabeth T. M. Leermakers , H. Rob Taal , Rachel Bakker , Eric A. P. Steegers , Albert Hofman , Vincent W. V. Jaddoe1,2,3* 1The Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands, 2 Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, 3 Department of Paediatrics, Erasmus Medical Center, Rotterdam, the Netherlands, 4 Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, the Netherlands Abstract Objective: Maternal smoking during pregnancy is associated with fetal growth retardation. We examined whether a common genetic variant at chromosome 15q25 (rs1051730), which is known to be involved in nicotine metabolism, modifies the associations of maternal smoking with fetal growth characteristics. Methods: This study was performed in 3,563 European mothers participating in a population-based prospective cohort study from early pregnancy onwards. Smoking was assessed by postal questionnaires and fetal growth characteristics were measured by ultrasound examinations in each trimester of pregnancy. Results: Among mothers who did not smoke during pregnancy (82.9%), maternal rs1051730 was not consistently associated with any fetal growth characteristic. Among mothers who continued smoking during pregnancy (17.1%), maternal rs1051730 was not associated with head circumference. The T-allele of maternal rs1051730 was associated with a smaller second and third trimester fetal femur length [dif