原创力文档a comparative analysis of glomerulus development in the pronephros of medaka and zebrafish前肾肾小球发展的比较分析青鳉和斑马鱼.pdfVIP
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a comparative analysis of glomerulus development in the pronephros of medaka and zebrafish前肾肾小球发展的比较分析青鳉和斑马鱼
A Comparative Analysis of Glomerulus Development in
the Pronephros of Medaka and Zebrafish
1,2 1 1 1
Koichiro Ichimura , Ekaterina Bubenshchikova , Rebecca Powell , Yayoi Fukuyo ,
1,3 4 5 6 4 2
Tomomi Nakamura , Uyen Tran , Shoji Oda , Minoru Tanaka , Oliver Wessely , Hidetake Kurihara ,
2 1
Tatsuo Sakai , Tomoko Obara *
1 Department of Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, United States of America, 2 Department of Anatomy and Life
Structure, Juntendo University School of Medicine, Tokyo, Japan, 3 Department of Biological Science and Technology, Graduate School of Industrial Science and
Technology, Tokyo University of Science, Noda, Chiba, Japan, 4 Department of Cell Biology, Lerner Research Institute/Cleveland Clinic Foundation, Cleveland, Ohio, United
States of America, 5 Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan, 6 Laboratory of
Molecular Genetics for Reproduction, National Institute for Basic Biology, Aichi, Japan
Abstract
The glomerulus of the vertebrate kidney links the vasculature to the excretory system and produces the primary urine. It is
a component of every single nephron in the complex mammalian metanephros and also in the primitive pronephros of fish
and amphibian larvae. This systematic work highlights the benefits of using teleost models to understand the pronephric
glomerulus development. The morphological processes forming the pronephric glomerulus are astoundingly different
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