原创力文档a comparison of urinary mercury between children with autism spectrum disorders and control children比较之间的尿汞自闭症谱系障碍的儿童和控制孩子.pdfVIP
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a comparison of urinary mercury between children with autism spectrum disorders and control children比较之间的尿汞自闭症谱系障碍的儿童和控制孩子
A Comparison of Urinary Mercury between Children with
Autism Spectrum Disorders and Control Children
1 2 3 4 1 5
Barry Wright *, Helen Pearce , Victoria Allgar , Jeremy Miles , Clare Whitton , Irene Leon , Jenny
1 1 6 6 5 7
Jardine , Nicola McCaffrey , Rob Smith , Ian Holbrook , John Lewis , David Goodall , Ben Alderson-
Day1
1 North Yorkshire and York Primary Care Trust, York, United Kingdom, 2 Tees Esk and Wear Valleys NHS Foundation Trust, Durham, United Kingdom, 3 Hull York Medical
School, York, United Kingdom, 4 RAND Corporation, Santa Monica, California, United States of America, 5 Food and Environment Research Agency, Sand Hutton, United
Kingdom, 6 York NHS Foundation Trust, York, United Kingdom, 7 Department Of Chemistry, York University, York, United Kingdom
Abstract
Background: Urinary mercury concentrations are used in research exploring mercury exposure. Some theorists have
proposed that autism is caused by mercury toxicity. We set out to test whether mercury concentrations in the urine of
children with autism were significantly increased or decreased compared to controls or siblings.
Methods: Blinded cohort analyses were carried out on the urine of 56 children with autism spectrum disorders (ASD)
compared to their siblings (n = 42) and a control sample of children without ASD in mainstream (n = 121) and special schools
(n = 34).
Results: There were no statistically significant differences in creatinine levels, in uncorrected urinary mercury levels or in
levels of mercury corrected for creatinine, whether or not the analysis is controlled fo
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