analysis and prediction of the metabolic stability of proteins based on their sequential features, subcellular locations and interaction networks分析和预测蛋白质的代谢稳定性基于时序特性,亚细胞位置和交互网络.pdfVIP

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analysis and prediction of the metabolic stability of proteins based on their sequential features, subcellular locations and interaction networks分析和预测蛋白质的代谢稳定性基于时序特性,亚细胞位置和交互网络.pdf

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analysis and prediction of the metabolic stability of proteins based on their sequential features, subcellular locations and interaction networks分析和预测蛋白质的代谢稳定性基于时序特性,亚细胞位置和交互网络

Analysis and Prediction of the Metabolic Stability of Proteins Based on Their Sequential Features, Subcellular Locations and Interaction Networks 1,2 4 4 5 2 3 4,6 Tao Huang , Xiao-He Shi , Ping Wang , Zhisong He , Kai-Yan Feng , LeLe Hu , Xiangyin Kong *, 1,2 3,7,8 8 Yi-Xue Li *, Yu-Dong Cai *, Kuo-Chen Chou * 1 Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China, 2 Shanghai Center for Bioinformation Technology, Shanghai, People’s Republic of China, 3 Institute of Systems Biology, Shanghai University, Shanghai, People’s Republic of China, 4 Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, 5 CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China, 6 State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China, 7 Centre for Computational Systems Biology, Fudan University, Shanghai, People’s Republic of China, 8 Gordon Life Science Institute, San Diego, California, United States of America Abstract The metabolic stability is a very important idiosyncracy of proteins that is related to their global flexibility, intramolecular fluctuations, various internal dynamic processes, as well as many marvelous biological functions. Determination of protein’s metabolic stability would provide us with useful information for in-dep