原创力文档regulation of adipose tissue stromal cells behaviors by endogenic oct4 expression control调节脂肪组织基质细胞行为的内生的oct4表达式控制.pdfVIP
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regulation of adipose tissue stromal cells behaviors by endogenic oct4 expression control调节脂肪组织基质细胞行为的内生的oct4表达式控制
Regulation of Adipose Tissue Stromal Cells Behaviors by
Endogenic Oct4 Expression Control
1. 1. 3 3 1 2
Jung Hwan Kim , Min Ki Jee , So Young Lee , Tae Hee Han , Bong Sun Kim , Kyung Sun Kang , Soo
Kyung Kang1*
1 Department of Veterinary Biotechnology, Seoul National University, Seoul, Republic of Korea, 2 Department of Veterinary Public Health, College of Veterinary Medicine,
Seoul National University, Seoul, Republic of Korea, 3 Department of Pharmacology, and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of
Korea
Abstract
Background: To clarify the role of the POU domain transcription factor Oct4 in Adipose Tissue Stromal Cells (ATSCs), we
investigated the regulation of Oct4 expression and other embryonic genes in fully differentiated cells, in addition to
identifying expression at the gene and protein levels. The ATSCs and several immature cells were routinely expressing Oct4
protein before and after differentiating into specific lineages.
Methodology/Principal Findings and Conclusions: Here, we demonstrated the role of Oct4 in ATSCs on cell proliferation
and differentiation. Exogenous Oct4 improves adult ATSCs cell proliferation and differentiation potencies through
epigenetic reprogramming of stemness genes such as Oct4, Nanog, Sox2, and Rex1. Oct4 directly or indirectly induces
ATSCs reprogramming along with the activation of JAK/STAT3 and ERK1/2. Exogenic Oct4 introduced a transdifferentiation
priority into the neural lineage than mesodermal lineage. Global gene expression analysis results showed that Oct4
regulated target genes which could be characterized as differentially regulated gen
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