removal of gabaa receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations删除对gabaa受体γ2子单元小清蛋白的神经元引起广泛的行为改变.pdfVIP

Removal of GABAA Receptor c2 Subunits from Parvalbumin Neurons Causes Wide-Ranging Behavioral Alterations ¨ 1 1 1 2,3 4 Elli Leppa , Anni-Maija Linden , Olga Y. Vekovischeva , Jerome D. Swinny , Ville Rantanen , Esko 5 ¨ 6 7 8¤a 8 ¤b 1 Toppila , Harald Hoger , Werner Sieghart , Peer Wulff , William Wisden * , Esa R. Korpi * 1 Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland, 2 Medical Research Council, Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford, United Kingdom, 3 Institute for Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, United Kingdom, 4 Research Programs Unit, Genome-Scale Biology, and Institute of Biomedicine, Biochemistry and Developmental Biology, University of Helsinki, Helsinki, Finland, 5 Finnish Institute of Occupational Health, Helsinki, Finland, 6 Core Unit of Biomedical Research, Division of Laboratory Animal Science and Genetics, Medical University Vienna, Himberg, Austria, 7 Department of Biochemistry and Molecular Biology, Center for Brain Research, Medical University Vienna, Vienna, Austria, 8 Department of Clinical Neurobiology, University of Heidelberg, Heidelberg, Germany Abstract We investigated the behavioral significance of fast synaptic inhibition by abc2-type GABAA receptors on parvalbumin (Pv) cells. The GABAA receptor c2 subunit gene was selectively inactivated in Pv-positive neurons b