原创力文档reprogramming of escherichia coli k-12 metabolism during the initial phase of transition from an anaerobic to a micro-aerobic environment重组大肠杆菌的k - 12的新陈代谢在初始阶段的过渡从厌氧微氧环境.pdfVIP
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reprogramming of escherichia coli k-12 metabolism during the initial phase of transition from an anaerobic to a micro-aerobic environment重组大肠杆菌的k - 12的新陈代谢在初始阶段的过渡从厌氧微氧环境
Reprogramming of Escherichia coli K-12 Metabolism
during the Initial Phase of Transition from an Anaerobic
to a Micro-Aerobic Environment
1 1 1 1
Eleanor W. Trotter , Matthew D. Rolfe , Andrea M. Hounslow , C. Jeremy Craven , Michael P.
1 2 1 1
Williamson , Guido Sanguinetti , Robert K. Poole , Jeffrey Green *
1 Department of Molecular Biology and Biotechnology, The Krebs Institute, University of Sheffield, Sheffield, United Kingdom, 2 Informatics Forum, University of
Edinburgh, Edinburgh, United Kingdom
Abstract
Background: Many bacteria undergo transitions between environments with differing O2 availabilities as part of their
natural lifestyles and during biotechnological processes. However, the dynamics of adaptation when bacteria experience
changes in O2 availability are understudied. The model bacterium and facultative anaerobe Escherichia coli K-12 provides an
ideal system for exploring this process.
Methods and Findings: Time-resolved transcript profiles of E. coli K-12 during the initial phase of transition from anaerobic
to micro-aerobic conditions revealed a reprogramming of gene expression consistent with a switch from fermentative to
respiratory metabolism. The changes in transcript abundance were matched by changes in the abundances of selected
central metabolic proteins. A probabilistic state space model was used to infer the activities of two key regulators, FNR (O2
sensing) and PdhR (pyruvate sensing). The model implied that both regulators were rapidly inactivated during the transition
from an anaerobic to a micro-aerobic environment. Analysis of the external metabolome and protein level
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