原创力文档requirement for abasic endonuclease gene homologues in arabidopsis seed development要求基本酶基因在拟南芥种子发展同系物.pdfVIP
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requirement for abasic endonuclease gene homologues in arabidopsis seed development要求基本酶基因在拟南芥种子发展同系物
Requirement for Abasic Endonuclease Gene Homologues
in Arabidopsis Seed Development
Terence M. Murphy*, Mark Belmonte, Stephanie Shu, Anne B. Britt, James Hatteroth
Section of Plant Biology, University of California Davis, Davis, California, United States of America
Abstract
Arabidopsis thaliana has three genes, Ape1L, Ape2, and Arp, that show homology to abasic (apurinic/apyrimidinic)
endonuclease genes of bacterial, yeast, or animal cells. In bacteria, yeast, and animals, abasic endonucleases function in base
excision repair of oxidized and other modified DNA bases. Here we report that plants with knock-out mutations in any one
of Ape1L, Ape2, or Arp show no apparent differences from wild type in growth rate, growth habit, and fertility. However,
coincident knock-out mutations in Ape1L and Ape2 are lethal and lead to abortion of developing embryos. Mutations of Arp
are not deleterious, even in combination with one of the other two mutations. The results are consistent with the
interpretation that the process of base excision repair, involving at least one intact copy of Ape1L or Ape2, is required in the
process of embryogenesis.
Citation: Murphy TM, Belmonte M, Shu S, Britt AB, Hatteroth J (2009) Requirement for Abasic Endonuclease Gene Homologues in Arabidopsis Seed
Development. PLoS ONE 4(1): e4297. doi:10.1371/journal.pone.0004297
Editor: Brian P Dilkes, Purdue University, United States of America
Received November 7, 2008; Accepted December 22, 2008; Published January 27, 2009
Copyright: 2009 Murphy et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: MB was supported by a
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