retinoid signaling in pancreatic cancer, injury and regeneration类维生素a信号在胰腺癌,损伤和再生.pdfVIP

Retinoid Signaling in Pancreatic Cancer, Injury and Regeneration 1 1 1,2 1 1 Emily K. Colvin , Johana M. Susanto , James G. Kench , Vivienna N. Ong , Amanda Mawson , Mark 1 1,3 1 1,2,4 1 Pinese , David K. Chang , Ilse Rooman , Sandra A. O’Toole , Davendra Segara , Elizabeth A. Musgrove1, Robert L. Sutherland1,4, Minoti V. Apte4,5, Christopher J. Scarlett1,6, Andrew V. Biankin1,3,4* 1 Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia, 2 Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, Camperdown, Australia, 3 Division of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, Australia, 4 St Vincent’s Clinical School, Faculty of Medicine, The University of New South Wales, Australia, 5 Pancreatic Research Group, South Western Sydney Clinical School, School of Medical Sciences, The University of New South Wales, Australia, 6 School of Environmental and Life Sciences, University of Newcastle, Ourimbah, Australia Abstract Background: Activation of embryonic signaling pathways quiescent in the adult pancreas is a feature of pancreatic cancer (PC). These discoveries have led to the development of novel inhibitors of pathways such as Notch and Hedgehog signaling that are currently in early phase clinical trials in the treatment of several cancer types. Retinoid signaling is also essential for pancreatic development, and retinoid therapy is used successfully in other malignancies such as leukemia, but little