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sensitive, noninvasive detection of lymph node metastases敏感,非侵入式检测淋巴结转移
Open access, freely available online PLoS MEDICINE
Sensitive, Noninvasive Detection
of Lymph Node Metastases
*
Mukesh G. Harisinghani, Ralph Weissleder
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Competing Interests: The authors
have declared that no competing A B S T R A C T
interests exist. RW is a member of
the editorial board of PLoS Medi-
cine. Background
Author Contributions: MGH con- Many primary malignancies spread via lymphatic dissemination, and accurate staging
ducted the study, analyzed the therefore still relies on surgical exploration. The purpose of this study was to explore the
data, and enrolled patients. RW
designed and conducted the study possibility of semiautomated noninvasive nodal cancer staging using a nanoparticle-enhanced
and analyzed the data. RW and lymphotropic magnetic resonance imaging (LMRI) technique.
MGH contributed to writing the
paper.
Methods and Findings
Academic Editor: Markus
Schwaiger, Technical University We measured magnetic tissue parameters of cancer metastases and normal unmatched
Munich, Germany
lymph nodes by noninvasive LMRI using a learning dataset consisting of 97 histologically
Citation: Harisinghani MG, Weis- proven nodes. We then prospectively tested the accuracy of these parameters against 216
sleder R (2004) Sensitive, noninva- histologically validated lymph nodes from 34 patients with primary cancers, in semiautomated
sive detection of lymph node
metastases. PLoS Med 1(3):
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