sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates mmp20 in human kidney aging连续使用的转录分析表达式定量特征映射,蕴涵和基因协会mmp20人类肾脏衰老.pdfVIP

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2017-09-09 发布于上海
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sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates mmp20 in human kidney aging连续使用的转录分析表达式定量特征映射,蕴涵和基因协会mmp20人类肾脏衰老.pdf

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sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates mmp20 in human kidney aging连续使用的转录分析表达式定量特征映射,蕴涵和基因协会mmp20人类肾脏衰老

Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping, and Gene Association Implicates MMP20 in Human Kidney Aging 1 2,3 2,3 4 5 Heather E. Wheeler , E. Jeffrey Metter , Toshiko Tanaka , Devin Absher , John Higgins , Jacob M. 6 6 6 7 4 2,3 Zahn , Julie Wilhelmy , Ronald W. Davis , Andrew Singleton , Richard M. Myers , Luigi Ferrucci , Stuart K. Kim1,8* 1 Department of Genetics, Stanford University Medical Center, Stanford, California, United States of America, 2 Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America, 3 Medstar Research Institute, Baltimore, Maryland, United States of America, 4 HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America, 5 Department of Pathology, Stanford University Medical Center, Stanford, California, United States of America, 6 Stanford Genome Technology Center, Palo Alto, California, United States of America, 7 Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America, 8 Department of Developmental Biology, Stanford University Medical Center, Stanford, California, United States of America Abstract Kidneys age at different rates, such that some people show little or no effects of aging whereas others show rapid functional decline. We sequentially used transcriptional profiling and expression quantitative trait loci (eQTL) mapping to narrow down which genes to test for association with kidney aging. We first performed whole-genome transcriptional pro