原创力文档sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin顺序7-dehydrocholesterol代谢甾族的5,7-dienes肾上腺皮肤及其生物学意义.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin顺序7-dehydrocholesterol代谢甾族的5,7-dienes肾上腺皮肤及其生物学意义
Sequential Metabolism of 7-Dehydrocholesterol to
Steroidal 5,7-Dienes in Adrenal Glands and Its Biological
Implication in the Skin
1 1 3 2 1
Andrzej T. Slominski *, Michal A. Zmijewski , Igor Semak , Trevor Sweatman , Zorica Janjetovic , Wei
4 5 6
Li , Jordan K. Zjawiony , Robert C. Tuckey
1 Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, 2 Department of Pharmacology, University of
Tennessee Health Science Center, Memphis, Tennessee, United States of America, 3 Department of Biochemistry, Belarus State University, Minsk, Belarus, 4 Department of
Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, 5 Department of Pharmacognosy, University of
Mississippi, Oxford, Mississippi, United States of America, 6 School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley,
Western Australia, Australia
Abstract
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential
7DHC metabolism by adrenal glands ex vivo. There was a rapid, time- and dose-dependent metabolism of 7DHC by adrenals
from rats, pigs, rabbits and dogs with production of more polar 5,7-dienes as detected by RP-HPLC. Based on retention time
(RT), UV spectra and mass spectrometry, we identified the major products common to all tested species as 7DHP, 22-hydroxy-
7DHC and 20,22-dihydroxy-7DHC. The involvement of P450scc in adrenal metabolic transformation was confirmed by the
inhibition of this process by DL-aminoglutethimide. The metabolism of 7DHC with subsequent producti
您可能关注的文档
- search algorithms as a framework for the optimization of drug combinations搜索算法的一个框架优化药物组合.pdf
- search for specific biomarkers of ifnβ bioactivity in patients with multiple sclerosis搜索特定的生物标志物ifnβ生物活性在多发性硬化症患者.pdf
- sds can be utilized as an amyloid inducer a case study on diverse proteins可以利用sds作为淀粉样蛋白诱导一个案例研究在不同的蛋白质.pdf
- s-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodelings-diclofenac防止doxorubicin-induced心肌病小鼠通过改善心肌缝隙连接重构.pdf
- searching pubmed during a pandemic搜索pubmed大流行期间.pdf
- searching for speciation genes molecular evidence for selection associated with colour morphotypes in the caribbean reef fish genus hypoplectrus寻找物种形成相关基因的分子证据选择颜色形态类型在加勒比海珊瑚礁鱼属hypoplectrus.pdf
- seas a system for seed-based pathway enrichment analysis海洋系统seed-based通路富集分析.pdf
- season of sampling and season of birth influence serotonin metabolite levels in human cerebrospinal fluid采样和季节的季节出生的5 -羟色胺影响人类代谢物水平的脑脊液.pdf
- season of birth and dopamine receptor gene associations with impulsivity, sensation seeking and reproductive behaviors出生的季节和多巴胺受体基因协会与冲动,感觉寻求和生殖行为.pdf
- searching for new clues about the molecular cause of endomyocardial fibrosis by way of in silico proteomics and analytical chemistry寻找新的线索endomyocardial纤维化的分子造成的硅片蛋白质组学和分析化学.pdf
- sequential broadening of ctl responses in early hiv-1 infection is associated with viral escape连续扩大ctl反应早期的hiv - 1感染病毒逃脱.pdf
- serial examination of an inducible and reversible dilated cardiomyopathy in individual adult drosophila串行检测诱导和可逆的扩张型心肌病的个体成年果蝇.pdf
- serial killing of tumor cells by human natural killer cells – enhancement by therapeutic antibodies连续杀害人类自然杀伤细胞,增强肿瘤细胞的治疗性抗体.pdf
- serial non-invasive measurements of dermal carotenoid concentrations in dairy cows following recovery from abomasal displacement串行的非侵入式测量真皮类胡萝卜素浓度在奶牛复苏abomasal位移.pdf
- ser276 phosphorylation of nf-kb p65 by msk1 controls scf expression in inflammationser276的磷酸化nf-kb p65 msk1控制自洽场表达式的炎症.pdf
- ser649 and ser650 are the major determinants of protein kinase a-mediated activation of human hormone-sensitive lipase against lipid substratesser649和ser650蛋白激酶的主要决定因素是一个调解的人类荷尔蒙激活脂肪酶对脂肪基质.pdf
- sequestration and tissue accumulation of human malaria parasites can we learn anything from rodent models of malaria封存和组织积累的人类疟原虫疟疾从啮齿动物模型,我们能学到什么.pdf
- seriation in paleontological data using markov chain monte carlo methods连续使用马尔可夫链蒙特卡罗方法在古生物学数据.pdf
- sequential assembly of centromeric proteins in male mouse meiosis着丝粒蛋白在雄性老鼠减数分裂的顺序组装.pdf
- serial position learning in honeybees系列位置学习蜜蜂.pdf
文档评论（0）