原创力文档serrano (sano) functions with the planar cell polarity genes to control tracheal tube length塞拉诺(sano)函数与平面细胞极性基因控制气管导管的长度.pdfVIP
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serrano (sano) functions with the planar cell polarity genes to control tracheal tube length塞拉诺(sano)函数与平面细胞极性基因控制气管导管的长度
Serrano (Sano) Functions with the Planar Cell Polarity
Genes to Control Tracheal Tube Length
1 1 1 2 2
SeYeon Chung , Melissa S. Vining , Pamela L. Bradley , Chih-Chiang Chan , Keith A. Wharton, Jr. ,
Deborah J. Andrew1*
1 Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2 Departments of Pathology and Molecular
Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Abstract
Epithelial tubes are the functional units of many organs, and proper tube geometry is crucial for organ function. Here, we
characterize serrano (sano), a novel cytoplasmic protein that is apically enriched in several tube-forming epithelia in
Drosophila, including the tracheal system. Loss of sano results in elongated tracheae, whereas Sano overexpression causes
shortened tracheae with reduced apical boundaries. Sano overexpression during larval and pupal stages causes planar cell
polarity (PCP) defects in several adult tissues. In Sano-overexpressing pupal wing cells, core PCP proteins are mislocalized
and prehairs are misoriented; sano loss or overexpression in the eye disrupts ommatidial polarity and rotation. Importantly,
Sano binds the PCP regulator Dishevelled (Dsh), and loss or ectopic expression of many known PCP proteins in the trachea
gives rise to similar defects observed with loss or gain of sano, revealing a previously unrecognized role for PCP pathway
components in tube size control.
Citation: Chung S, Vining MS, Bradley PL, Chan C-C, Wharton KA, Jr., et al. (2009) Serrano (Sano) Functions with the Planar Cell Polarity Genes to Control Tracheal
Tube Length. PLoS Genet 5(11): e1000746. doi:10.1371/journal.pgen.1000746
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