原创力文档serum 25-hydroxyvitamin d3 and d2 and non-clinical psychotic experiences in childhood血清人体内25 -羟维生素d3和d2和非临床精神病的童年经历有关.pdfVIP
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serum 25-hydroxyvitamin d3 and d2 and non-clinical psychotic experiences in childhood血清人体内25 -羟维生素d3和d2和非临床精神病的童年经历有关
Serum 25-Hydroxyvitamin D3 and D2 and Non-Clinical
Psychotic Experiences in Childhood
1 2 3 2 2,4
Anna-Maija Tolppanen , Adrian Sayers , William D. Fraser , Glyn Lewis , Stanley Zammit ,
5 1
John McGrath , Debbie A. Lawlor *
1 MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, 2 School of
Social and Community Medicine, University of Bristol, Bristol, United Kingdom, 3 Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 4 MRC
Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom, 5 Queensland Centre for Mental Health Research and Department of
Psychiatry and Queensland Brain Institute, University of Queensland, St Lucia, Australia
Abstract
Objective: Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin
D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-
hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different
forms of 25(OH)D, (25(OH)D and 25(OH)D , have similar associations with psychosis-related outcomes.
3 2
Methods: We investigated the association between serum 25(OH)D3 and 25(OH)D2 concentrations and psychotic
experiences in a prospective birth cohort study. Serum 25(OH)D3 and 25(OH)D2 concentrations were measured at mean age
9.8 years and psychotic experiences assessed at mean age 12.8 years by
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