原创力文档serum amyloid p aids complement-mediated immunity to streptococcus pneumoniae对肺炎链球菌血清淀粉样蛋白p艾滋病complement-mediated免疫力.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
serum amyloid p aids complement-mediated immunity to streptococcus pneumoniae对肺炎链球菌血清淀粉样蛋白p艾滋病complement-mediated免疫力
Serum Amyloid P Aids Complement-Mediated
Immunity to Streptococcus pneumoniae
1 2 1 1*
Jose Yuste , Marina Botto , Stephen E. Bottoms , Jeremy S. Brown
1 Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom, 2 Molecular
Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, London, United Kingdom
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined,
although they are likely to be important, as no natural state of SAP deficiency has been reported. We have investigated
the role of SAP for innate immunity to the important human pathogen Streptococcus pneumoniae. Using flow
cytometry assays, we show that SAP binds to S. pneumoniae, increases classical pathway–dependent deposition of
complement on the bacteria, and improves the efficiency of phagocytosis. As a consequence, in mouse models of
infection, mice genetically engineered to be SAP-deficient had an impaired early inflammatory response to S.
pneumoniae pneumonia and were unable to control bacterial replication, leading to the rapid development of fatal
infection. Complement deposition, phagocytosis, and control of S. pneumoniae pneumonia were all improved by
complementation with human SAP. These results demonstrate a novel and physiologically significant role for SAP for
complement-mediated immunity against an important bacterial pathogen, and provide further evidence for the
importance of the classical complement pathway for innate immunity.
Citation: Yuste J, Botto M, Bottoms SE, Brown JS (2007) Serum amyloid P
您可能关注的文档
- sedlin forms homodimers characterisation of sedlin mutations and their interactions with transcription factors mbp1, pitx1 and sf1sedlin形式为描述sedlin突变与转录因子及其交互mbp1,pitx1 sf1.pdf
- seed density significantly affects species richness and composition in experimental plant communities种子密度显著影响实验植物群落物种丰富度和组成.pdf
- seedling stage strategies as a means of habitat specialization in herbaceous plants苗期策略是草本植物的栖息地的专业化.pdf
- seed-based biclustering of gene expression dataseed-based biclustering基因表达数据.pdf
- seed spillage from grain trailers on road verges during oilseed rape harvest an experimental survey从谷物种子溢出拖车在道路边缘油菜收获一个实验调查.pdf
- segmental duplications arise from pol32-dependent repair of broken forks through two alternative replication-based mechanisms节段复制来自pol32-dependent修复破碎的叉通过两种replication-based机制.pdf
- seeds of destruction predicting how micrornas choose their target破坏预测小分子核糖核酸的种子选择自己的目标.pdf
- seeing ‘where’ through the ears effects of learning-by-doing and long-term sensory deprivation on localization based on image-to-sound substitution看到u201c地方u201d通过耳朵边干边学和长期的感官剥夺对定位的影响基于image-to-sound替换.pdf
- segmentation and visual analysis of whole-body mouse skeleton microspect分割和可视化分析,全身骨骼microspect老鼠.pdf
- secretory vesicles are preferentially targeted to areas of low molecular snare density分泌囊泡是优先目标地区的低分子陷阱密度.pdf
- serum bdnf concentrations show strong seasonal variation and correlations with the amount of ambient sunlight血清bdnf浓度显示强劲的季节性变化和相关性的周围的阳光.pdf
- serum fetuin-a associates with type 2 diabetes and insulin resistance in chinese adults血清fetuin-a协会与中国成人2型糖尿病和胰岛素抵抗.pdf
- serum her2 level measured by dot blot a valid and inexpensive assay for monitoring breast cancer progression血清her2水平衡量点吸干一个有效和廉价的检验监测乳腺癌进展.pdf
- serum iga responses against pertussis proteins in infected and dutch wp or ap vaccinated children an additional role in pertussis diagnostics血清对百日咳的iga反应蛋白在感染和荷兰wp或者美联社接种孩子额外在百日咳诊断中的作用.pdf
- serum level of cc-chemokine ligand 18 is increased in patients with non-small-cell lung cancer and correlates with survival time in adenocarcinomas血清水平cc-chemokine 18增加配体在非小细胞肺癌患者和与腺癌生存时间.pdf
- serum levels of tweak and scavenger receptor cd163 in type 1 diabetes mellitus relationship with cardiovascular risk factors. a case-control study血清水平的调整和清道夫受体cd163在1型糖尿病与心血管危险因素的关系。.pdf
- serum activity of platelet-activating factor acetylhydrolase is a potential clinical marker for leptospirosis pulmonary hemorrhage血清acetylhydrolase platelet-activating活动因素是潜在的临床标记钩端螺旋体病肺出血.pdf
- serum levels of choline-containing compounds are associated with aerobic fitness level the hunt-study血清水平的choline-containing化合物与有氧健身水平hunt-study相关联.pdf
- serum ige reactivity profiling in an asthma affected cohort血清ige反应分析哮喘影响队列.pdf
- serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease血清脂肪酸结合蛋白4是一个预测心血管疾病的终末期肾病.pdf
文档评论（0）