原创力文档serum fetuin-a associates with type 2 diabetes and insulin resistance in chinese adults血清fetuin-a协会与中国成人2型糖尿病和胰岛素抵抗.pdfVIP
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serum fetuin-a associates with type 2 diabetes and insulin resistance in chinese adults血清fetuin-a协会与中国成人2型糖尿病和胰岛素抵抗
Serum Fetuin-A Associates with Type 2 Diabetes and
Insulin Resistance in Chinese Adults
1 1 1 1 1 1 1 1 1
Aiyun Song , Min Xu , Yufang Bi , Yu Xu , Yun Huang , Mian Li , Tiange Wang , Yaohua Wu , Yu Liu ,
1,2 1 1 1,2
Xiaoying Li , Yuhong Chen , Weiqing Wang , Guang Ning *
1 Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism,
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2 State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to
Shanghai Jiao Tong University School of Medicine, Shanghai, China
Abstract
Background: Previous studies have demonstrated that fetuin-A is related to insulin resistance among subjects with normal
glucose tolerance but not patients with type 2 diabetes. There are limited data available concerning fetuin-A and insulin
resistance in Chinese. We aimed to study the association of feuin-A with insulin resistance among participants with or
without type 2 diabetes in a large sample size of adults aged 40 and older.
Methodology and Principal Findings: A community-based cross-sectional study was performed among 5,227 Chinese
adults. The average age of our study was 61.5 69.9 years. Serum fetuin-A concentrations were not significantly different
between male and female (296.9 vs. 292.9 mg/l, p = 0.11). Compared with the lowest quartile, the highest quartile of serum
fetuin-A revealed a significant higher proportion of type 2 diabetic patients (34.8% vs. 27.3%, p,0.0001). In the multinomial
logit models,
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