原创力文档serum levels of choline-containing compounds are associated with aerobic fitness level the hunt-study血清水平的choline-containing化合物与有氧健身水平hunt-study相关联.pdfVIP
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serum levels of choline-containing compounds are associated with aerobic fitness level the hunt-study血清水平的choline-containing化合物与有氧健身水平hunt-study相关联
Serum Levels of Choline-Containing Compounds Are
Associated with Aerobic Fitness Level: The HUNT-Study
1,2. 1 . 1,2 ˚ 1 1
Anja Bye , Riyas Vettukattil * , Stian T. Aspenes , Guro F. Giskeødegard , Ingrid S. Gribbestad ,
Ulrik Wisløff1,2, Tone F. Bathen 1
1 Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, 2 K. G. Jebsen Center of Exercise in Medicine,
Trondheim, Norway
Abstract
Background: Cardiovascular disease (CVD) is a leading cause of death worldwide, and the number of people at risk is
continuously growing. New methods for early risk prediction are therefore needed to actuate prevention strategies before
the individuals are diagnosed with CVD. Several studies report that aerobic fitness level, measured as maximal oxygen
uptake (VO2max), is the single best predictor of future CVD mortality in healthy people. Based on this, we wanted to study
differences between healthy individuals with a large difference in VO2max-level to identify new biomarkers of low aerobic
fitness that may also have potential as early biomarkers of CVD risk.
Methodology/Principal Findings: Serum samples from 218 healthy individuals with a low VO2max (n = 108, 63 women) or
high VO2max (n = 110, 64 women) were analysed with MR metabolomics. In addition, standard clinical-chemical analyses for
glucose, lipids, liver enzymes, micro-CRP, and colorimetric analysis on circulating choline were performed. Individuals in the
low VO2max-group had increased serum levels of free choli
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