原创力文档serum retinol-binding protein 4 as a marker for cardiovascular disease in women血清蛋白质retinol-binding 4作为女性心血管疾病的标志.pdfVIP
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serum retinol-binding protein 4 as a marker for cardiovascular disease in women血清蛋白质retinol-binding 4作为女性心血管疾病的标志
Serum Retinol-Binding Protein 4 as a Marker for
Cardiovascular Disease in Women
1,3 2,3 4 3
Khalid M. Alkharfy *, Nasser M. Al-Daghri , Paul M. Vanhoutte , Soundararajan Krishnaswamy ,
Aimin Xu4,5
1 Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, 2 Biochemistry Department, College of Science, King Saud University,
Riyadh, Saudi Arabia, 3 Biomarkers Research Program, College of Science, King Saud University, Riyadh, Saudi Arabia, 4 Department of Pharmacology and Pharmacy,
Faculty of Medicine, The University of Hong Kong, Hong Kong, 5 Department of Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong
Abstract
Background: Elevated serum level of retinol-binding protein 4 (RBP4) has been associated with obesity-related co-
morbidities including insulin resistance, dyslipidemia and hypertension.
Objectives: The present study examined the relationship between serum level of RBP4 and various risk factors related to
cardiovascular disease (CVD) in men and women.
Methods: 284 subjects (139 males, 145 females), grouped into healthy (n = 60), obese diabetes (n = 60), non-obese diabetes
(n = 60), obese non-diabetes (n = 60) and patients with CVD (n = 44), were assessed for anthropometric and biochemical
parameters related to obesity, diabetes and CVD. In addition, serum levels of several adipokines, including fatty acid binding
protein 4 (FABP4) and lipocalin 2 (LCN2) and RBP4 were measured using specific immunoassays.
Results: Serum RBP4 level correlated significantly with principal component derived from known risk factors of CVD
(b = 0.2060.06, P = 0.002). Significance of this cor
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