原创力文档serum α-tocopherol and γ-tocopherol concentrations and prostate cancer risk in the plco screening trial a nested case-control study血清α-tocopherol和全方位γ-tocopherol浓度和前列腺癌风险筛查试验一个嵌套病例对照研究.pdfVIP
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serum α-tocopherol and γ-tocopherol concentrations and prostate cancer risk in the plco screening trial a nested case-control study血清α-tocopherol和全方位γ-tocopherol浓度和前列腺癌风险筛查试验一个嵌套病例对照研究
Serum a-Tocopherol and c-Tocopherol Concentrations
and Prostate Cancer Risk in the PLCO Screening Trial: A
Nested Case-Control Study
1 2,3 4 5 6
Stephanie J. Weinstein *, Ulrike Peters , Jiyoung Ahn , Marlin D. Friesen , Elio Riboli ,
4 1
Richard B. Hayes , Demetrius Albanes *
1 Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and
Human Servies, Bethesda, Maryland, United States of America, 2 Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
of America, 3 Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, United States of America, 4 Division of Epidemiology,
Department of Population Health, New York University School of Medicine, New York, New York, United States of America, 5 Department of Environmental Health
Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, 6 Department of Epidemiology and Public Health, Imperial
College, London, United Kingdom
Abstract
Background: Vitamin E compounds exhibit prostate cancer preventive properties experimentally, but serologic
investigations of tocopherols, and randomized controlled trials of supplementation in particular, have been inconsistent.
Many studies suggest protective effects among smokers and for aggressive prostate cancer, however.
Methods: We conducted a nested case-control study of serum a-tocopherol and c-tocopherol and prostate cancer risk in
the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
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