原创力文档serum microrna-122 predicts survival in patients with liver cirrhosis血清microrna - 122预测肝硬化患者的生存期.pdfVIP
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serum microrna-122 predicts survival in patients with liver cirrhosis血清microrna - 122预测肝硬化患者的生存期
Serum MicroRNA-122 Predicts Survival in Patients with
Liver Cirrhosis
¨ .
Oliver Waidmann*, Verena Koberle, Friederike Brunner, Stefan Zeuzem, Albrecht Piiper ,
Bernd Kronenberger.
¨
Department of Medicine 1, Klinikum der Goethe-Universitat, Frankfurt, Germany
Abstract
Background: Liver cirrhosis is associated with high morbidity and mortality. MicroRNAs (miRs) circulating in the blood are an
emerging new class of biomarkers. In particular, the serum level of the liver-specific miR-122 might be a clinically useful new
parameter in patients with acute or chronic liver disease.
Aim: Here we investigated if the serum level of miR-122 might be a prognostic parameter in patients with liver cirrhosis.
Methods: 107 patients with liver cirrhosis in the test cohort and 143 patients in the validation cohort were prospectively
enrolled into the present study. RNA was extracted from the sera obtained at the time of study enrollment and the level of
miR-122 was assessed. Serum miR-122 levels were assessed by quantitative reverse-transcription PCR (RT-PCR) and were
compared to overall survival time and to different complications of liver cirrhosis.
Results: Serum miR-122 levels were reduced in patients with hepatic decompensation in comparison to patients with
compensated liver disease. Patients with ascites, spontaneous bacterial peritonitis and hepatorenal syndrome had
significantly lower miR-122 levels than patients without these complications. Multivariate Cox regression analysis revealed
that the miR-122 serum levels were associated with survival independently from the MELD score, sex and age.
Conclusions: Serum miR-
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