serum and cerebrospinal fluid autoantibodies in patients with neuropsychiatric lupus erythematosus. implications for diagnosis and pathogenesis血清和脑脊液神经精神病学的红斑狼疮患者自身抗体。.pdfVIP

Serum and Cerebrospinal Fluid Autoantibodies in Patients with Neuropsychiatric Lupus Erythematosus. Implications for Diagnosis and Pathogenesis 1 1 ´ 2 ´ 2 Hilda Fragoso-Loyo , Javier Cabiedes , Alejandro Orozco-Narvaez , Luis Davila-Maldonado , Yemil 1 3 1 ´ 1 Atisha-Fregoso , Betty Diamond , Luis Llorente , Jorge Sanchez-Guerrero * ´ ´ ´ ´ ´ 1 Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, Distrito Federal, Mexico, 2 Department of ´ ´ ´ ´ ´ Neurology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, Distrito Federal, Mexico, 3 The Feinstein Institute for Medical Research, Manhasset, New York, United States of America Abstract Background: Despite the uncertainty in the diagnosis of neuropsychiatric involvement in systemic lupus erythematosus (SLE), attempts have been made to record the association of certain antibodies in serum with neuropsychiatric (NP) manifestations. We aimed to assess the behaviour and the association of serum and cerebrospinal fluid (CSF) autoantibodies with NP manifestations in SLE patients (NPSLE). Methodology/Principal Findings: Forty-seven SLE patients, hospitalized because of NP manifestations were included. They were evaluated at hospitalization and six months later, and serum and CSF samples were obtained at each evaluation. As controls, serum sampl