原创力文档serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease血清脂肪酸结合蛋白4是一个预测心血管疾病的终末期肾病.pdfVIP
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serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease血清脂肪酸结合蛋白4是一个预测心血管疾病的终末期肾病
Serum Fatty Acid-Binding Protein 4 Is a Predictor of
Cardiovascular Events in End-Stage Renal Disease
1 1 1 2 3
Masato Furuhashi *, Shutaro Ishimura , Hideki Ota , Manabu Hayashi , Takahiro Nishitani , Marenao
1 1 4 ¨ 5 1
Tanaka , Hideaki Yoshida , Kazuaki Shimamoto , Gokhan S. Hotamisligil , Tetsuji Miura
1 Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, 2 Second Department of Internal Medicine, Obihiro Kosei
Hospital, Obihiro, Japan, 3 Obihiro East Medical and Cardiovascular Clinic, Obihiro, Japan, 4 Sapporo Medical University, Sapporo, Japan, 5 Department of Genetics and
Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
Abstract
Background: Fatty acid-binding protein 4 (FABP4/A-FABP/aP2), a lipid chaperone, is expressed in both adipocytes and
macrophages. Recent studies have shown that FABP4 is secreted from adipocytes and that FABP4 level is associated with
obesity, insulin resistance, and atherosclerosis. However, little is known about the impact of FABP4 concentrations on
prognosis. We tested the hypothesis that FABP4 level predicts prognosis of patients with end-stage renal disease (ESRD), a
group at high risk for atherosclerosis-associated morbidity and mortality.
Methods and Results: Biochemical markers including FABP4 were determined in 61 ESRD patients on chronic hemodialysis
(HD). Serum FABP4 level in females (404.2630.5 ng/ml) was significantly higher than that in males (315.8 630.0 ng/ml), and
the levels in ESRD patients were about 20-times higher than those in age-, gender- and body m
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