serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis血清脂多糖结合蛋白水平预测肺损伤的严重程度和死亡率在严重脓毒症患者.pdfVIP

Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis ´ 1,2,3 ´ ´ 1,4 5 1,4 ´ 1,6 6 Jesus Villar *, Lina Perez-Mendez , Elena Espinosa , Carlos Flores , Jesus Blanco , Arturo Muriel , ´ 1,4, Mercedes Muros1,7, Lluis Blanch1,8, Antonio Artigas1,8, Robert M. Kacmarek9,10 for Santiago Basaldua the GRECIA and GEN-SEP groups¤ 1 CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, 2 Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain, 3 Associate scientist, Keenan Research Center, St. Michael’s Hospital, Toronto, Canada, 4 Research Unit, Hospital Universitario NS de Candelaria, Tenerife, Spain, 5 Department of Anesthesiology, Hospital Universitario NS de Candelaria, Tenerife, Spain, 6 Intensive Care Unit, Hospital Universitario Rio Hortega, Valladolid, Spain, 7 Department of Clinical Biochemistry, Hospital Universitario NS de Candelaria, Tenerife, Spain, ´ ´ 8 Critical Care Center, Corporacio Sanitaria Parc Taulı, Sabadell, Barcelona, Spain, 9 Department of Respiratory Care, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 10 Department of Anesthesia, Harvard University, Boston, Massachusetts, United States of America Abstract Background: There is a need for biomarkers insuring identification of septic patients at high-risk for death. We performed a prospective, multicenter, observational study to investigate the time-cour