原创力文档serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes血清晚期糖基化终末产物水平和其它标记的蛋白质损伤在1型糖尿病的早期糖尿病肾病.pdfVIP
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serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes血清晚期糖基化终末产物水平和其它标记的蛋白质损伤在1型糖尿病的早期糖尿病肾病
Serum Levels of Advanced Glycation Endproducts and
Other Markers of Protein Damage in Early Diabetic
Nephropathy in Type 1 Diabetes
1 . 2. 2 3
Bruce A. Perkins * , Naila Rabbani , Andrew Weston , Linda H. Ficociello ,
2 3 3 3
Antonysunil Adaikalakoteswari , Monika Niewczas , James Warram , Andrzej S. Krolewski ,
Paul Thornalley2
1 Division of Endocrinology, University of Toronto, Toronto, Canada, 2 Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry,
United Kingdom, 3 Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts, United States of America
Abstract
Objective: To determine the role of markers of plasma protein damage by glycation, oxidation and nitration in
microalbuminuria onset or subsequent decline of glomerular filtration rate (termed ‘‘early GFR decline’’) in patients with
type 1 diabetes.
Methods: From the 1st Joslin Kidney Study, we selected 30 patients with longstanding normoalbuminuria and 55 patients
with new onset microalbuminuria. Patients with microalbuminuria had 8–12 years follow-up during which 33 had stable
GFR and 22 early GFR decline. Mean baseline GFRCYSTATIN C was similar between the three groups. Glycation, oxidation and
nitration markers were measured in protein and ultrafiltrate at baseline by liquid chromatography-tandem mass
spectrometry using the most reliable methods currently available.
Results: Though none were significantly different between patients with microalbuminuria with stable or early GFR decline,
levels of 6 protein
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