原创力文档serum level of cc-chemokine ligand 18 is increased in patients with non-small-cell lung cancer and correlates with survival time in adenocarcinomas血清水平cc-chemokine 18增加配体在非小细胞肺癌患者和与腺癌生存时间.pdfVIP
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serum level of cc-chemokine ligand 18 is increased in patients with non-small-cell lung cancer and correlates with survival time in adenocarcinomas血清水平cc-chemokine 18增加配体在非小细胞肺癌患者和与腺癌生存时间
Serum Level of CC-Chemokine Ligand 18 Is Increased in
Patients with Non-Small-Cell Lung Cancer and Correlates
with Survival Time in Adenocarcinomas
¨ 1 2 2 4 1 ¨
Till Plones , Alexander Krohn , Meike Burger , Hendrik Veelken , Bernward Passlick , Joachim Muller-
3 3
Quernheim , Gernot Zissel *
1 Department of Thoracic Surgery, University Medical Center Freiburg, Freiburg, Germany, 2 Department of Oncology and Haematology, University Medical Center
Freiburg, Freiburg, Germany, 3 Department of Pneumology, University Medical Center Freiburg, Freiburg, Germany, 4 Department of Haematology, Leiden University
Medical Center, Leiden, The Netherlands
Abstract
CC-chemokineligand18(CCL18)ismainlyexpressedbyalternativelyactivatedmacrophagesandDCsandplaysanimportantrole
in lung fibrosis, arthritis and other diseases. Here CCL18 was measured in sera of 31healthy volunteers and 170 patients with lung
cancerandcorrelatedthesedatawithhistology,tumorstageandclinicalparameters.MeanCCL18serumlevelofthepatientswith
non-small-cell lung cancer was 150(857) ng/ml vs. 32(61) ng/ml in the healthy control group. Patient groups differ significantly
accordingtheirhistology(adenocarcinoma143(528) ng/mlvssquamouscellcarcinoma187(857)ng/ml,p,0.02).Inaddition,we
found a significant difference between patients with lower versus higher T-stage (p,0.003). Receiver operating characteristic
(ROC)analysesrevealedacutoffpointof83 ng/ml(areaunderthecurve(AUC):0.968;p,0.0001)todiscriminatebetweenhealthy
controls and non-small-cell lung cancer patients. ROC analyses to discriminate between patients, who died because of cancer
relateddeathandthosewhodiedforotherreasonsdidnotleadtoavalidAUC. Tostratifythetumor patients,acrit
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