原创力文档serum iga responses against pertussis proteins in infected and dutch wp or ap vaccinated children an additional role in pertussis diagnostics血清对百日咳的iga反应蛋白在感染和荷兰wp或者美联社接种孩子额外在百日咳诊断中的作用.pdfVIP
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serum iga responses against pertussis proteins in infected and dutch wp or ap vaccinated children an additional role in pertussis diagnostics血清对百日咳的iga反应蛋白在感染和荷兰wp或者美联社接种孩子额外在百日咳诊断中的作用
Serum IgA Responses against Pertussis Proteins in
Infected and Dutch wP or aP Vaccinated Children: An
Additional Role in Pertussis Diagnostics
1,2 ¨ ¨ 1 1 1 3
Lotte H. Hendrikx *, Kemal Ozturk , Lia G. H. de Rond , Sabine C. de Greeff , Elisabeth A. M. Sanders ,
Guy A. M. Berbers1, Anne-Marie Buisman1
1 Centre for Infectious Disease and Control (Clb), National Institute for Public Health and the Environment, Bilthoven, The Netherlands, 2 Research Centre Linnaeus
institute, Spaarne Hospital Hoofddorp, Hoofddorp, The Netherlands, 3 Department of Pediatric Immunology and Infectious Diseases, University Medical Centre Utrecht,
Utrecht, The Netherlands
Abstract
Background: Whooping cough is a respiratory disease caused by Bordetella pertussis, which induces mucosal IgA antibodies
that appear to be relevant in protection. Serum IgA responses are measured after pertussis infection and might provide an
additional role in pertussis diagnostics. However, the possible interfering role for pertussis vaccinations in the induction of
serum IgA antibodies is largely unknown.
Methods/Principal Findings: We compared serum IgA responses in healthy vaccinated children between 1 and 10 years of
age with those in children who despite vaccinations recently were infected with Bordetella pertussis. All children have been
vaccinated at 2, 3, 4 and 11 months of age with either the Dutch whole-cell pertussis (wP) vaccine or an acellular pertussis
(aP) vaccine and additionally received an aP booster vaccination at 4 years of age. Serum IgA responses to pertussis toxin
(PT), filamentous heamagglutinin (FHA) and pertactin (Prn) were measured with a fluorescent multiplex bead-based
immuno-assay. An EL
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