serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in african children血清而2水平区分脑型疟疾从简单的疟疾和预测非洲儿童的临床结果.pdfVIP

Serum Angiopoietin-1 and -2 Levels Discriminate Cerebral Malaria from Uncomplicated Malaria and Predict Clinical Outcome in African Children 1 2 3 1 1 Fiona E. Lovegrove , Noppadon Tangpukdee , Robert O. Opoka , Erin I. Lafferty , Nimerta Rajwans , 1 2 2{ 4 1,5. Michael Hawkes , Srivicha Krudsood , Sornchai Looareesuwan , Chandy C. John , W. Conrad Liles , Kevin C. Kain1,5.* 1 McLaughlin-Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada, 2 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 3 Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda, 4 Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America, 5 Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada Abstract Background: Limited tools exist to identify which individuals infected with Plasmodium falciparum are at risk of developing serious complications such as cerebral malaria (CM). The objective of this study was to assess serum biomarkers that differentiate between CM and non-CM, with the long-term goal of developing a clinically informative prognostic test for severe malaria. Methodology/Principal Findings: Based on the hypothesis that endothelial activation and blood-brain-barrier dysfunction contribute to CM pathogenesis, we examined the endothelial regulators, angiopoietin-1 (ANG-1) and angiop