stretch activates human myometrium via erk, caldesmon and focal adhesion signaling延伸通过erk激活人类子宫肌层,caldesmon和粘着斑信号.pdfVIP

Stretch Activates Human Myometrium via ERK, Caldesmon and Focal Adhesion Signaling 1,2 1 3 1 4 5 Yunping Li *, Maya Reznichenko , Rachel M. Tribe , Philip E. Hess , Michael Taggart , HakRim Kim , 6 5 2,5 Jon P. DeGnore , Samudra Gangopadhyay , Kathleen G. Morgan 1 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America, 3 Division of Reproduction and Endocrinology, King’s College London, London, United Kingdom, 4 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 5 Health Sciences Department, Boston University, Boston, Massachusetts, United States of America, 6 Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America Abstract An incomplete understanding of the molecular mechanisms responsible for myometrial activation from the quiescent pregnant state to the active contractile state during labor has hindered the development of effective therapies for preterm labor. Myometrial stretch has been implicated clinically in the initiation of labor and the etiology of preterm labor, but the molecular mechanisms involved in the human have not been determined. We investigated the mechanisms by which gestation-dependent stretch contributes to myometrial activation, by using human uterine samples from gynecologic hysterectomies and Cesarean sections. Here we demonstrate that the Ca requirement