poems 综合征(讲座)（诗综合征（讲座））.docVIP

poems 综合征(讲座)（诗综合征（讲座）） POEMS syndrome (Lecture) General Hospital of PLA neurology department Sun Bin First, the etiology and pathogenesis of POEMS syndrome (1) autoimmune diseases associated with abnormal immunoglobulin produced by plasma cell proliferation. The clinical use of immunosuppressive agents in patients with isolated plasma cell tumor after resection or radiotherapy can significantly improve the condition, decrease in serum gamma globulin and negative M protein, support the above view. The abnormal immunoglobulin produced by malignant B lymphocytes or plasma cells or chromosomal abnormalities caused by the gene has not been conclusive. (two) IL-6 is related to its pathogenesis It was reported recently that the patients with blood, chest ascites, interleukin water, glomerular and vascular endothelial cells in -6 (IL-6) increased after treatment decreased, in addition to the known IL-6 terminal differentiation induced by B cells, can stimulate proliferation of plasma cells, so IL-6 and its pathogenesis. Some people believe that with the bone marrow plasma cell chromosome variation. The data showed that the vascular endothelial growth factor (VEGF) levels decreased after steroid treatment improved, suggesting that VEGF played an important role in the pathogenesis of the disease. (three) the mechanism needs to be studied The pathogenesis is not very clear. May M and secretion of proteins or plasma cells in the lymph live toxic effects on the peripheral nervous system, endocrine glands, bones, reticuloendothelial system, hematopoietic system and immune system; also may be associated with high blood viscosity. The relationship between amyloid deposition and opinion varies from one view to another. Because the treatment of focal myeloma can improve the symptoms of peripheral neuropathy and skin changes, it is also considered that this syndrome is a distant effect of tumor. There are some patients with trichloroethylene, pesticides, organic solvents and other ex