基于米诺环素在皮肤性病中的合理应用（Rational use of minocycline in skin and venereal diseases）.docVIP

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基于米诺环素在皮肤性病中的合理应用（Rational use of minocycline in skin and venereal diseases）.doc

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基于米诺环素在皮肤性病中的合理应用（Rational use of minocycline in skin and venereal diseases）

基于米诺环素在皮肤性病中的合理应用（Rational use of minocycline in skin and venereal diseases） Rational use of minocycline in skin and venereal diseases Date: 07, 21 Minocycline (two minocycline, minocycline, Minocycline, minocin) is the second generation of tetracycline, a semisynthetic tetracycline, chemically called 7-, two methylamine, -6-, demethylation, -6-, and tetracycline. The utility model is suitable for treating various mild and moderate infections caused by sensitive pathogenic bacteria, and has better clinical curative effect. 1 general pharmacological function [1~2] Minocycline is a broad-spectrum antibiotic and has similar pharmacological functions as tetracycline, but it has more powerful functions. 1.1 antibacterial Abstract: it is sensitive to Gram-positive bacteria and negative bacteria, especially to tetracycline resistant strains. It also has antibacterial activity to aerobic bacteria and anaerobic bacteria, and also has inhibitory function to Mycoplasma and chlamydia. Minocycline is mainly antibacterial, but high concentration also has bactericidal function. 1.2 inhibition of lymphocyte activity Abstract: minocycline can significantly inhibit the mitogen responsive response of lymphocytes to phytohemagglutinin (PHA); 1.3 、 anti inflammation Abstract: minocycline has the function of inhibiting the chemotaxis of neutrophils and inhibiting the inflammation and the function of oxygen intermediates; 1.4 collagenase activity Abstract: collagenase activity depends on calcium and zinc and minocycline can exert calcium and zinc levels through its chelating function. 1.5 inhibition of sebum secretion Abstract: minocycline can significantly reduce the level of facial skin free fatty acid, with the treatment time extended, reducing the amount of free fatty acids, more after stopping the drug can still maintain this function. 1.6 function summary of protein metabolism: blocking protein synthesis by blocking the binding of amino sulfhydryl -S-RNA and RNA ribosome complex. 1.