降压用药（Antihypertensive drugs）.doc

降压用药（Antihypertensive drugs） Inhibition of bradykinin reduced the bradykinin degradation and played a hypotensive role. Applicable to all types of hypertension, especially for the following situations: hypertension and left ventricular hypertrophy, left ventricular dysfunction or heart failure, myocardial infarction, diabetes, hypertension and renal damage in peripheral vascular disease. In addition to the hypotensive effect, it also exerts beneficial effects on the cardiovascular system through a variety of mechanisms, and is an excellent cardiovascular drug. Irritating cough, however, limits its use to some extent. Pregnancy and renal artery stenosis, renal failure (creatinine, 265, mol/L or 3mg/dL) are prohibited. 6) angiotensin II receptor blockers play a hypotensive role by directly blocking the angiotensin II receptor. The clinical effect was the same as that of ACE inhibitors, but no adverse reactions such as cough. The clinic is mainly applicable to patients whose ACE inhibitors are intolerant. Characteristics of short, medium and long-acting antihypertensive drugs The duration of antihypertensive drugs is based on the duration of effective maintenance of the drug in the bloodstream. Short acting antihypertensive drugs generally last about 5~8 hours. Nifedipine usually takes about 5 hours and captopril is about 6 hours. Therefore, you must take it three times a day, otherwise you can not guarantee effective antihypertensive effect. The maintenance time of this kind of medicine is not long, but the action time is very fast. For example, nifedipine takes only 3~15 minutes, and captopril takes 15~30 minutes. Therefore, these drugs are used as first aid medicine when the blood pressure suddenly rises. The median effective blood pressure is maintained in the blood for about 10~12 hours. Such as Nifedipine Controlled Release Tablets, after taking the lowest maintenance effective blood concentration of drugs in more than 12 hours, nitrendipine can also maintain 6~1