组织工程化皮肤从形态和功能安全替代的前景.docVIP

组织工程化皮肤：从形态和功能安全替代的前景 王晓静1，王国伟2，惠光艳1，赵铱民3 (1解放军海军青岛第一疗养院口腔科，山东省青岛市 266071；2解放军海军第401医院崂山分院口腔科，山东省青岛市 266061；3解放军第四军医大学口腔医院，陕西省西安市 710032) 引用本文：王晓静，王国伟，惠光艳，赵铱民. 组织工程化皮肤：从形态和功能安全替代的前景[J].中国组织工程研究，2017，21(): 2600-2605. DOI:10.3969/j.issn.2095-4344.2017.16.024 ORCID: 0000-0001-8771-1099(王晓静) 文章快速阅读： 文题释义： 真皮组织作用：Integra人造皮肤：issue-engineered skin substitutes: a prospect evaluation from the aspects of morphology and function Wang Xiao-jing1, Wang Guo-wei2, Hui Guang-yan1, Zhao Yi-min3 (1Department of Stomatology, Qingdao First Sanatorium of PLA Navy, Qingdao 266071, Shandong Province, China; 2Department of Stomatology, Laoshan Branch of No. 401 Hospital of PLA Navy, Qingdao 266061, Shandong Province, China; 3Stomatological Hospital of the Fourth Military Medical University, Xi’an 710032 , Shaanxi Province, China) Abstract BACKGROUND: Tissue engineering is a booming subject in recent years, involving skin, cornea, bone, cartilage, tendon and etc. Noticeably, tissue-engineered skin is an issue of concern, which provides an alluring prospect for the repair of skin defects. OBJECTIVE: To overview the latest research progress of tissue-engineered skin. METHODS: A computer-based research of Medline database from 1996 to 2017 was performed, with the English keywords of “epidermis, dermis, tissue engineered skin”. The latest research status of tissue-engineered skin was summarized in views of epidermal and dermal substitutes, followed by exploring the problems and prospects of tissue-engineered skin. RESULTS AND CONCLUSION: A total of 65 literatures were included. Complex skin substitutes include epidermis and dermis, in which hair follicles, sweat glands, sebaceous glands and other cutaneous appendages are absent. Therefore, how to solve above problems is a hotspot issue and major trend in tissue-engineered skin. Tissue-engineered skin aims to construct permanent skin substitutes containing melanocytes and Langerhans cells rapidly. Since the current tissue-engine