两种不同剂量胺碘酮对心力衰竭并发快速房颤患者临床疗效分析.docVIP

两种不同剂量胺碘酮对心力衰竭并发快速房颤患者临床疗效分析 　 【关键词】; 胺碘酮；心房颤动；心力衰竭,充血性；心率 毕业论文 ［摘要］; 目的; 探讨不同剂量胺碘酮，对充血性心力衰竭伴快速心房颤动患者的有效性及安全性。方法; 选取36例快速房颤患者(心室率gt;120 bpm，心功能NYHA分级≥Ⅱ级)，随机分成两个不同剂量组，每组18例。两组每次静脉给予的负荷剂量分别为75 mg、150 mg，首次给予胺碘酮(生理盐水稀释成20 ml)缓慢静脉注射15 min，如不转复为窦性心律，以相同的剂量每30 min重复一次达4次。结果; 两组控制房颤伴快速心室率的总有效率分别为69%、77%(Pgt;0.05)。两组心室率在用药30 min后平均下降幅度分别为(6.12±6.24)bpm、(15.09±8.98)bpm，两组比较差异有统计学意义(Plt;0.01)，用药1 h后平均下降幅度分别为(13.62±10.87)bpm、(19.56±12.38)bpm(Plt;0.01)，用药2 h后平均下降幅度分别为(30.69±21.25)bpm、(28.57±13.46)bpm(Pgt;0.05)。两组用药后Q-T间期、血压差异无统计学意义(Pgt;0.05)。患者均无严重心律失常发生，未诱发或加重心功能不全。结论; 静脉应用两种不同剂量胺碘酮均能快速、安全、有效控制充血性心力衰竭并发快速心房颤动患者心室率，并能使部分患者转复。较大剂量组能够更快控制房颤患者心室率，但不良反应发生率提高。 毕业论文 ; ［关键词］; 胺碘酮；心房颤动；心力衰竭，充血性；心率 毕业论文 Clinical evaluation on intravenous amiodarone with two doses for congestive heart failure with rapid atrial fibrillation 毕业论文 ［Abstract］; Objective; To evaluate efficacy and safety of intravenous amiodarone with two does for congestive heart failure with rapid atrial fibrillation.Methods; Thirtysix patients with rapid atrial fibrillation (ventricular rate gt;120 beats per minute and cardiac function≥gradeⅡ) were divided into two groups. A group has 18 patients. The bolus dosage of group 1 and guorp 2 is 75 mg and 150 mg in turn. The first bolus of amiodarone was given intravenously,repeated with the same dose half an hour for four times if no efficacy shown.Results; Total efficacy rate of the two groups was 69%,77%,respectively(Pgt;0.05). The decrease amplitude of ventricular rate after the first bolus was (6.12±6.24)bpm,(15.09±8.98)bpm,respectively. Very significant difference was found between group 1 and group 2. After the second bolus it was (13.62±10.87)bpm,(19.56±12.38)bmp respectively (Plt;0.01). After the fourth bolus it was (30.69±21.25)bpm,(28.57±13.46) bpm.Respectively (Pgt;0.05). There was no significant difference on Q-T interval blood pressure after injection in the two groups. There was neither severe arrhythmia nor induced or worsened heart dysfunction am