中药复方脂肝乐抗大鼠脂肪肝作用.docVIP

中药复方脂肝乐抗大鼠脂肪肝作用 　【关键词】 脂肪肝； 脂质过氧化作用； 中成药； 大鼠，Wistar； 脂肝乐 　　［Abstract］ Objective: To explore the curative effect of Chinese herbal compounds, Zhiganle to hepatic adiposis in rats induced by high fat diet, and to study its mechanism. Method: Wistar rats were randomly divided into 6 groups: Normal control （NC）, pathological model （PM）, Dongbaogantai treated group （DT）, and 3 Zhiganle treatment groups that received different dosages of Zhiganle （ZT1 1.5 g·kg-1·d-1, ZT2 3.0 g·kg-1·d-1, and ZT3 4.5 g·kg-1·d-1）. All the experimental rats except those in group NC, were given high fat diet for 12 weeks and then fed with normal diet. Began in the 13th week, rats in group DT were administered with Dongbaogantai（0.3 g·kg-1·d-1）, and rats in groups ZT1, ZT2, and ZT3 received Zhiganle for other 12 weeks. Rats in NC were given normal saline instead. Finally, all the rats were executed, and their serum triglyceride （TG）, serum total cholesterol （T-CH）, hepatic TG, hepatic T-CH, glutathione （GSH）, malonaldehyde （MDA） and hepatic pathological changes were checked. Results: Levels of serum TG, serum T-CH, hepatic TG, hepatic T-CH, and MDA were clearly higher （Plt;0.01 or Plt;0.05） and GSH level obviously lower （Plt;0.01 or Plt;0.05） in group PM than those in group NC; the levels of serum TG, serum T-CH, hepatic TG, hepatic T-CH, and MDA in treatment groups were clearly lower （Plt;0.01 and Plt;0.05） and GSH level in the liver remarkably higher （Plt;0.01 and Plt;0.05） than those in group PM. Hepatic pathological changes were lightened in treated groups than those in group PM. Conclusion: Zhiganle has good treating effects on hepatic adiposis in rats induced by high fat diet. 　　［Key words］ fatty liver; lipid peroxidation; ready-made patent drugs; rats,Wistar; Zhiganle 脂肪肝是由多种疾病和原因引起的肝脏脂肪变性。国内外学者认为当肝细胞合成甘油三酯（TG）及分泌极低密度脂蛋白（VLDL）不平衡时，脂肪肝就会形成。对于脂肪肝的治疗，目前临床上尚缺乏较满意的药物。已报道的考来烯胺、烟酸肌醇酯、苯扎贝特、吉非罗齐等药物虽然可以从不同环节抑制脂肪肝，但不良反应多、疗程长，故临床应用受到限制［1］。根据传统中医理论活血化瘀、疏肝解郁、健脾化湿研制出的中药复方脂肝乐（简称ZGL）是由草决明、山楂、泽泻等多味中药组成，临