乌灵胶囊及美利曲辛治疗伴有焦虑症状功能性消化不良对照探究.docVIP

乌灵胶囊及美利曲辛治疗伴有焦虑症状功能性消化不良对照探究 　【关键词】; 乌灵胶囊；美利曲辛；功能性消化不良；焦虑 毕业论文 　　【摘要】 目的; 探讨乌灵胶囊治疗伴轻中度焦虑症状的功能性消化不良患者的疗效及安全性。 方法; 将60例伴轻中度焦虑症状的功能性消化不良患者随机分为两组各30例。研究组给予乌灵胶囊治疗（失访1例），对照组给予美利曲辛治疗（失访4例），疗程均为6w。采用汉密顿焦虑量表、水负荷试验评定临床疗效，副反应量表评定不良反应。 结果; 治疗6w末，两组汉密顿焦虑量表评分均明显降低（P＜0.01），焦虑改善总有效率分别为58.6%和61.5%，水负荷量均明显增加（P＜0.05），两组疗效相当，均未见明显不良反应。 结论; 乌灵胶囊治疗伴有轻、中度焦虑的功能性消化不良患者的焦虑症状疗效显著、安全性高、依从性好。 毕业论文 　　【关键词】 乌灵胶囊；美利曲辛；功能性消化不良；焦虑 毕业论文 　　A control study of Wuling capsule and deanxit in the treatment of functional dyspepsia　 毕业论文 　　【Abstract】 Objective; To explore the efficacy and safety of Wuling capsule in the treatment of functional dyspepsia (FD) accompanied with mild to moderate anxiety. Methods; 60 patients were randomly divided into 2 groups: Wuling capsule group (n=30，one dropped) treated with Wuling capsule and Deanxit group(n=30，four dropped) with Deanxit for 6 weeks. Clinical efficacy was assessed with the Hamilton Anxiety Scale (HAMA ) and the waterloading test and the sideeffects with the Treatment Emergent Symptoms Scale (TESS). Results; After 6week treatment, scores of the HAMA of both 2 groups significantly reduced(Plt;0.01)，total effective rate of anxiety improvement were 58.6% and 61.5% respectively, water loading significantly increased (Plt;0.05), clinical efficacies were equivalent and side effects not significant. Conclusion; Wuling capsule has significant effectiveness, high safety and well compliance in the treatment of FD accompanied with mild to moderate anxiety. 毕业论文 　　【Keywords】; Wuling capsule; deanxit; functional dyspepsia; anxiety ; 　　功能性消化不良（functional dyspepsia,FD）是消化系统的常见疾病。由于其发病原因复杂多样，发病机制尚未完全明确，目前多采用促动力、制酸和消化酶等制剂治疗，但疗效欠佳。近年来有报道表明［1］，精神心理因素与FD的发生密切相关。临床调查显示，≥70％的FD患者伴有焦虑或抑郁情绪。为此，我们采用乌灵胶囊与美利曲辛（黛力新）治疗伴有轻、中度焦虑的FD患者进行了对照研究，以探讨乌灵胶囊治疗FD的疗效及安全性，现将结果报告如下。 毕业论文 　　1 对象与方法 毕业论文 　　1.1 对象; 选取在我院门诊治疗的60例FD患者为研究对象。入组标准：（1）均符合罗马Ⅱ标准的FD诊断标准［2］。（2）性别不限，年龄18～65a。（3）汉密顿焦虑量表（Hamilton Anxiety Scale,HAMA）评分12～24分。（4）入组前2w内未服用任何影响胃肠道动力的药物和抗焦虑、抑郁剂，如有用药，则进行2w清洗期。将入组病例随机分为两组各