哮喘儿童Clara细胞分泌蛋白及肺功能相关性及临床意义.docVIP

哮喘儿童Clara细胞分泌蛋白及肺功能相关性及临床意义 　 作者：温志红，谢庆玲，胡琼燕，杜华 【关键词】 Clara细胞分泌蛋白；肺功能；哮喘；儿童 　　Relationship between Clara cell secretory protein levels and lung function in asthmatic children 　　【Abstract】 AIM: To evaluate the clinical significances of Clara cell secretory protein (CCSP), and the correlation between CCSP levels and lung function in children with asthma. METHODS: Sera were collected from 29 cases during asthmatic attacks, among them 16 asthmatic children being in stable conditions after treatment, and 20 healthy children as controls. Serum CCSP concentrations were measured by a human CCSP enzymelinked immunosorbent assay (ELISA). Lung function was monitored in children with asthma. RESULTS: Asthmatic children appeared significantly lower levels of CCSP in sera during asthmatic attacks ［(5.49±2.52） μg/L］ or in stable conditions［(9.25±3.38） μg/L］ as compared to healthy ones ［(12.31±3.90） μg/L, Plt;0.001］, espically those in acute asthma. Furthermore, there was a strongly positive correlation between serum CCSP and FEV1, FEV1/FVC, FEF25, FEF50, FEF75, PEFR in asthmatic children.CONCLUSION: CCSP may play a role in controlling inflammation in the airway and protecting the pulmonary function in chronic asthma. 　　【Keywords】 Clara cell secretory protein; lung function; asthma; child 　　【摘要】 目的： 探讨哮喘儿童Clara细胞分泌蛋白(CCSP)与肺功能的关系及临床意义. 方法： 采用酶联免疫吸附法检测29例哮喘急性发作期儿童血清CCSP水平，其中16例患儿经治疗后于缓解期采血复查，另设20例健康对照. 同步检测哮喘儿童肺功能. 结果： 哮喘急性发作期、缓解期儿童血清CCSP水平［分别为(5.49±2.52) μg/L, (9.25±3.38) μg/L］均较健康对照组儿童低［(12.31±3.90) μg/L，Plt;0.001］，在急性发作期尤为明显. 哮喘儿童急性发作期、缓解期CCSP浓度与FEV1, FEV1/FVC, FEF25, FEF50, FEF75, PEFR均呈正相关. 结论： CCSP具有抗哮喘气道炎症作用；CCSP对肺功能可能起到保护作用. 　　【关键词】 Clara细胞分泌蛋白；肺功能；哮喘；儿童 　　0引言 　　Clara细胞分泌蛋白（CCSP）具有抗炎症、抗纤维化作用［1-2］，它与哮喘等呼吸系统疾病的关系日益受到重视. 而肺功能检测和结果判断是哮喘诊断和疗效判断的重要参考指标. 200407/200510，我们检测29例哮喘儿童血清CCSP水平，并探讨CCSP与肺功能的关系及临床意义. 　　1对象与方法 　　1.1对象29例患儿均为我院儿科住院或哮喘专科病人，符合支气管哮喘诊断标准［3］. 年龄3.5~11(平均5.8)岁；男18例，女11例；首次就诊未使用糖皮质激素. 对照组20(男13，女7)例；年龄3~12(平均6.2)岁；无喘息性疾病或特应体质；无糖皮质激素使用史. 哮喘组和对照组儿童均否认肝、肾、心疾病及内分泌疾病；第二性