原创力文档a comparative population-based study of prostate cancer incidence and mortality rates in singapore, sweden and geneva, switzerland from 1973 to 2006比较基于人群的研究前列腺癌的发病率和死亡率在新加坡、瑞典和瑞士日内瓦从1973年到2006年.pdfVIP
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a comparative population-based study of prostate cancer incidence and mortality rates in singapore, sweden and geneva, switzerland from 1973 to 2006比较基于人群的研究前列腺癌的发病率和死亡率在新加坡、瑞典和瑞士日内瓦从1973年到2006年
Chen et al. BMC Cancer 2012, 12:222
/1471-2407/12/222
RESEARCH ARTICLE Open Access
A comparative population-based study of
prostate cancer incidence and mortality rates in
Singapore, Sweden and Geneva, Switzerland from
1973 to 2006
1 1 1 1,2 1,3 4
Cynthia Chen , Nasheen Naidoo , Qian Yang , Mikael Hartman , Helena M Verkooijen , En Yun Loy ,
5 1 1*
Christine Bouchardy , Kee Seng Chia and Sin Eng Chia
Abstract
Background: Prostate cancer is the most commonly diagnosed malignancy in men in Sweden and Geneva, and
the third most common in men in Singapore. This population-based study describes trends in the incidence and
mortality rates of prostate cancer in Singapore, Sweden and Geneva (Switzerland) from 1973 to 2006 and explores
possible explanations for these different trends.
Methods: Data from patients diagnosed with prostate cancer were extracted from national cancer registries in
Singapore (n = 5,172), Sweden (n = 188,783) and Geneva (n = 5,755) from 1973 to 2006. Trends of incidence and
mortality were reported using the Poisson and negative binomial regression models. The age, period and birth-
cohort were tested as predictors of incidence and mortality rates of prostate cancer.
Results: Incidence rates of prostate cancer increased over all time periods for all three populations. Based on the
age-period-cohort analysis, older age and later period of diagnosis were associated with a higher incidence of
prostate cancer, whereas older age and earlier period were associated with higher mortality rates for prostate
cancer in all three countries.
Conclusions: This study demonstrated an overall increase in in
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