石杉碱甲治疗精神分裂症认知功能下降医学措施.doc

石杉碱甲治疗精神分裂症认知功能下降医学措施 　【摘要】 目的:探讨石杉碱甲对精神分裂症患者认知功能的影响。方法:对70例精神分裂症稳定期患者随机分为研究组与对照组,原治疗用药方案在观察期间不变,研究组加用石杉碱甲,对照组继续原用药方案。观察治疗8周,采用简明精神病评定量表(BPRS)、韦氏成人记忆量表修订本(WMS-RC)和威斯康星卡片分类测验(WCST)评定治疗前后患者认知功能的改变。结果:治疗8周后,研究组各项认知功能指标均有不同程度的改善,而对照组只有WCST中持续反应数和数字广度测验较治疗前显著好转,其余各指标两组间无显著差异。研究组除WCST中持续反应数和WMS-CR中数字广度外,其它各指标均显著优于对照组(Plt;0.05)。结论:石杉碱甲能有效改善精神分裂症患者的记忆功能和认知功能,毒性小,副反应不明显,优于单用抗精神病药物治疗。　　【关键词】 石杉碱甲; 精神分裂症; 认知功能 　　Evaluate the Therapeutic Efficacy of Huperzine A on Decline in Cognitive Function of Psychosis/ZHANG Shao-xia.//Medical Innovation of China,2012,9(28):006-008　　【Abstract】 Objective:To study the effects of huperzine A on cognitive function in patients with psychosis.Method:Seventy cases of psychosis patients were randomly divided into the experimental group and the control group,and treated with anticholinergic drugs or anticholinergic drugs with huperzine A for 8 weeks.All patients were assessed in pretreatment and post-treatment by brief psychiatric rating scale(BPRS),WMS-RC and WCSF after 8 weeks treatment.Result:All indices of cognitive function improved of the control group,while only persistent responses (PR) and digit span test in WCST improved significantly in experimental group,the rest indices could not show difference between the two groups. After 7 weeks treatment, except index of PR in WCST and digit span in WMS-CR,the other indices in control group were significantly better than that in experiment group (Plt;0.05).Conclusion:Anticholinergic drugs with huperzine A can effectively improve their memory function with low toxicity.Meanwhile the side effeces are not obvious,and is better than applied with anticholinergic drugs alone. 　　【Key words】 Huperzine A; Psychosis; Cognitive function　　First-authors address:The Xinyong Hospital of Dongguan City,Dongguan 523000,China 毕业论文 　　doi:10.3969/j.issn.1674-4985.2012.28.003　　认知功能下降是精神分裂症患者常见的核心症状[1],其症可能与颞叶、额叶皮层及皮层下结构功能低下有关。精神分裂症患者主要表现为出现幻觉、幻想、情感不协调、情感平淡、动机缺乏等一些阳性或阴性症状,而认知功能下降是指除了阳性症状和阴性症状之外的第3个症状成分[2]。石杉碱甲是一种可逆性乙