药学监护对高尿酸血症患者疗效及用药依从性影响.docVIP

药学监护对高尿酸血症患者疗效及用药依从性影响 　【摘要】 目的：探讨药学监护对有症状高尿酸血症患者疗效与用药依从性的影响。方法：对有症状高尿酸病人进行用药分析，健康知识教育和生活方式干预，干预 4 周，8 周后观察病人血尿酸的变化，用药依从性，用药疗效。结果：药学监护干预治疗后血尿酸（BUA）明显下降，差异均有显著意义（P lt; 0.05），干预前后高尿酸患者用药依从性显著提高（ =124.262，P lt; 0.01），病人对药师的咨询明显增加（ =50.8465，P lt; 0.05），患者不良生活习惯明显改善（P lt; 0.01）结论：药学监护可以提高高尿酸病人用药疗效及用药依从性，改善不良的生活习惯，对预防高尿酸血症并发症的发生有重要的作用。 【关键词】 高尿酸；药学监护；用药依从性 Influence of Pharmaceutical Care on the Curative Effect and Medication Compliance of Patients with Hyperuricemia LI Fan （Department of Pharmacy, Shenzhen Second People’s Hospital, Guangdong Shenzhen 518035） 〔Abstract〕 Objective To investigate the impact of pharmaceutical care on the symptoms of patients with hyperuricemia and patients’ medication compliance. Methods To analysis drug use, health education and lifestyle intervention of symptomatic patients with high serum uric acid, after four weeks and eight weeks, observing the changes of medication compliance and drug efficacy in serum uric acid. Results After pharmaceutical care intervention treatment, the serum uric acid (BUA) had significantly decreased (P lt; 0.05), medication compliance of patients with hyperuricemia significantly increased ( =124.262, P lt; 0.01), patients on the drug advisory increased significantly ( =50.8465, P lt; 0.05), patients with unhealthy living habits significantly improved (P lt; 0.01). Conclusion Pharmaceutical care can improve drug efficacy and patient medication compliance and improve the lives of poor accustomed of high uric acid patients, and has played an important role on decreasing the incidence of complications in hyperuricemia. 〔Key Words〕 High uric acid; Pharmaceutical care; Medication compliance 尿酸是人体内嘌吟代谢的主要产物，血尿酸水平与生活方式和社会心理因素相关密切[1]，高尿酸血症可以无症状，但是可以促发冠心病、高血压和肾功能损害；也可因尿酸盐结晶沉积于关节，形成痛风性关节炎，时间长久后尿酸盐结晶（MSU）逐渐形成痛风石[2]。为避免高尿酸血症的危害, 预防糖尿病心脑血管疾病的发生，对有症状的高尿酸血症要积极干预治疗。为此，我们选取了 60 例有症状高尿酸血症的病人进行药学监护干预，观察治疗前及治疗后 4 周和 8 周时血尿酸的变化。 1 资料与方法 1.1 一般资料 60 例均为 2007 年 4 月 - 2007 年 7 月在本院门诊就诊或住院的病人，男 52 例，女 8 例。年龄 40~60 岁。体重指数〔21.1~3