原创力文档a new pooling strategy for high-throughput screening the shifted transversal design一个新的池大规模筛选移位的横向设计的策略.pdfVIP
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a new pooling strategy for high-throughput screening the shifted transversal design一个新的池大规模筛选移位的横向设计的策略
BMC Bioinformatics BioMed Central
Research article Open Access
A new pooling strategy for high-throughput screening: the Shifted
Transversal Design
Nicolas Thierry-Mieg*
Address: Laboratoire Logiciels-Systèmes-Réseaux, IMAG Institute, BP53, 38041 Grenoble Cedex 9, France
Email: Nicolas Thierry-Mieg* - Nicolas.Thierry-Mieg@imag.fr
* Corresponding author
Published: 19 January 2006 Received: 17 June 2005
Accepted: 19 January 2006
BMC Bioinformatics2006, 7:28 doi:10.1186/1471-2105-7-28
This article is available from: /1471-2105/7/28
© 2006Thierry-Mieg; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: In binary high-throughput screening projects where the goal is the identification of
low-frequency events, beyond the obvious issue of efficiency, false positives and false negatives are
a major concern. Pooling constitutes a natural solution: it reduces the number of tests, while
providing critical duplication of the individual experiments, thereby correcting for experimental
noise. The main difficulty consists in designing the pools in a manner that is both efficient and
robust: few pools should be necessary to correct the errors and identify the positives, yet the
experiment should not be too v
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